Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library.

نویسندگان

  • Dianqing Sun
  • Victoria Jones
  • Elizabeth I Carson
  • Robin E B Lee
  • Michael S Scherman
  • Michael R McNeil
  • Richard E Lee
چکیده

A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. High-throughput screening of this library for anti-tuberculosis activity identified several members with a MIC(90) value of 12.5 microg/mL.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 17 24  شماره 

صفحات  -

تاریخ انتشار 2007